Brain scans of people who were overweight or obese looked about 8 years older, and low estrogen, testosterone or thyroid hormone also sped up brain aging, so fixing metabolism, hormones and nutrition can visibly restore brain structure.

• What to do: Treat the brain through the body. Track cardiometabolic health, hormones and nutrients, and add a brain MRI with quantitative analysis plus Alzheimer's blood markers when family history or age 50 to 60 makes them relevant.
• Why it matters: Brain changes can show up about 30 years before Alzheimer's, and around 60% of people diagnosed with dementia have cardiometabolic problems. Scans show recovery after nutrition is restored, as in anorexia, where the brain improved most.
• How to apply it: Get a broad blood panel that includes vitamin D, iron, omega 3, heavy metals, insulin, thyroid, sex hormones, homocysteine and methylmalonic acid, then retest after changes to see your trend.
• Metrics: Alzheimer's incidence doubles every 5 years after age 70, from about 5% at 70 to 10% at 75 and 20% at 80. One APOE4 copy roughly triples risk, and two copies (about 6% of people) raise it 9 to 10 times. Key markers include p tau 217, amyloid beta 42/40, neurofilament light and GFAP.
• Tools: Functional MRI, PET, NeuroQuant brain age and brain charts, plus the Function Health panel. Sponsors named in the episode: Bon Charge red light mask, Paleovalley bars, Timeline Mitopure, Seed DS 01, BiOptimizers magnesium and Fatty15.
• Risks: A single marker or a normal structural MRI can miss the problem, because many psychiatric conditions show up in function, not structure. Imaging is more controversial than blood work.
• Exceptions: Only about 2% of Alzheimer's cases are directly genetic. APOE4 tilts risk but is not destiny, and its effect varies by ancestry.

Bone mineral density predicts only about 70% of fracture risk because a two-dimensional DEXA misses bone shape, and lifting challenging loads can thicken the femoral neck cortex even when hip density barely changes.

• What to do: Do two strength sessions a week built on a squat, hinge, push, pull and carry, add balance moves and keep up daily activity such as walking, dancing or shoveling.
• Why it matters: Bone mass peaks in your 20s and about 5% of the skeleton is remodeled every year, so the goal after 65 is to hold on to bone and prevent falls.
• How to apply it: Use 8 to 12 repetitions, pick difficulty rather than maximum weight, try walking lunges and step-ups, and add a few sets of 10 to 12 small hops if your joints allow.
• Metrics: BMD explains about 70% of fracture risk, FRAX estimates 10 year fracture probability, and CTX and P1NP track bone resorption and formation.
• Tools: DEXA with 3D hip analysis, FRAX, a machine circuit for beginners, Function Health tests, Prolon and Momentous creatine appear in the episode.
• Risks: Calling an X-ray bone on bone can scare people away from exercise, and heavy loads with poor form raise injury risk for beginners.
• Exceptions: For someone using a walker with severe arthritis, the goal is function and fall prevention, not bone density.

Robert Greene argues that the sublime is not a rare event but a shift in attention: after about a minute of sustained focus on a single object, as Ouspensky practiced with a vase of flowers, the ordinary starts to look strange and alive, and months of practice changed how he saw whole streets.

• What to do: Practice self remembering. Pick a simple object, look at it for a full minute and tell yourself you will remember this moment. Repeat daily. Greene also meditates for 40 minutes every morning, and says meditation changes brain wiring.
• Why it matters: Splintered attention makes time feel too fast. Greene says childhood felt long because there was empty space between thoughts, and that a constantly interrupted mind is more vulnerable to influence and advertising.
• How to apply it: Keep your phone in a drawer while you work, write by hand when you need deep thinking (Greene filled over 100 notebooks), and spend time with things that are not human: a backyard, the ocean, a mountain, an animal. Experience first and report later, instead of filming everything.
• Tools: Handwriting, meditation, music listened to note by note, and journaling about your earliest memories to find your life's task.
• Risks: Filming a concert or hike splits your attention between living and reporting. Huberman also warns that drugs such as MDMA can attach strong meaning to trivial things.
• Exceptions: Not everyone has a clear childhood seed moment. Greene says finding it can take days or weeks of digging, looking at what you loved and also at what frustrates you.

Sauerkraut is not a probiotic: a probiotic is a specific strain with a known genome and clinical or randomized trial evidence, while the live microbes in sauerkraut, kimchi or kombucha are just live microbes, and only some yogurt brands list strains backed by evidence.

• What to do: Pick supplements or yogurts that print the strain name, take them with food and swap products if you notice no change after a trial period. Eat varied fiber and a mix of ferments such as yogurt, kefir, sourdough, tempeh and sauerkraut.
• Why it matters: Strains of the same species can act oppositely (EHEC E. coli vs the harmless E. coli in your gut), and a 37 study review of fermented dairy found benefits for gut symptoms, serum TNF alpha and gut barrier function.
• How to apply it: Store probiotics cool, dry and away from oxygen. If you avoid dairy, use plant-based yogurt, water kefir or kvass, whose microbes also survive in the gut. Treat commercial stool tests as information, and talk to a doctor or dietitian about persistent symptoms.
• Metrics: 37 fermented dairy studies; kimchi vs cabbage over 3 weeks; fecal calprotectin for inflammation and zonulin for gut wall function.
• Tools: Strain labels and the US probiotic guideline; stool tests only to detect pathogens such as C. diff.
• Risks: Wrongly handled food can carry Clostridium botulinum, and washing produce does not remove all pathogens.
• Exceptions: Most microbes pass through rather than settle, so the benefit depends on regular intake.

Obstructive sleep apnea can stop or sharply reduce your breathing dozens of times an hour without you remembering it, which is why eight hours in bed can still leave you foggy, with morning headaches and blood pressure that is hard to control.

• What to do: Do not diagnose yourself from a podcast or a smartwatch. If you snore loudly, wake with a dry mouth or headache, or feel exhausted after eight hours, ask your doctor for a home sleep test or a night in a sleep lab.
• Why it matters: Untreated apnea is associated with high blood pressure, atrial fibrillation, heart failure, coronary disease, stroke, insulin resistance, type 2 diabetes and trouble with memory and focus. Mark Hyman describes a patient who lost 50 pounds without trying after starting treatment.
• How to apply it: Use CPAP now and investigate causes at the same time. If the mask leaks or dries your mouth, try a nasal mask or pillows, heated humidity, a heated tube or a different pressure setting. Limit alcohol, stop smoking, review medications such as opioids and treat nasal congestion.
• Metrics: Doctors track the AHI, the apnea hypopnea index, which counts breathing events per hour of sleep. Retest after weight loss or surgery to confirm it improved.
• Tools: Function Health offers over 160 lab tests for $365 a year, including insulin and glucose, useful because thyroid and metabolic problems can contribute.
• Risks: Mouth tape is not a treatment for suspected sleep apnea, and stopping CPAP because you feel better can hide a problem that is still there.
• Exceptions: Being thin or fit does not rule it out, and women often show fatigue, headaches or insomnia instead of loud snoring.

A registered dental hygienist names four 2026 favorites they use and recommend to patients: the Quip Rev oscillating toothbrush, GUM Professional Clean floss picks, Sensodyne Clinical Repair toothpaste and the Quip rechargeable cordless water flosser.

• What to do: Choose an affordable oscillating toothbrush, durable floss picks that do not fray and a sensitivity toothpaste with enamel remineralization, then add a water flosser if you want extra cleaning.
• Why it matters: Technique decides results. Guide an electric brush slowly from tooth to tooth and never scrub, and floss by hugging the tooth up and down on each side.
• How to apply it: Subscribe to brush head refills every 3 months, keep floss picks in your bag, car and desk, and start the water flosser on its gentle mode before moving to deep clean pressure.
• Tools: Quip Rev, GUM Professional Clean Floss Picks, Sensodyne Clinical Repair and the Quip water flosser.
• Risks: The Sensodyne version they use contains SLS, which can irritate some mouths. Check the label for an SLS-free option if you have irritation.
• Exceptions: Sensodyne costs more than some pastes, and the water flosser category is crowded, so compare options if budget matters.

GLP-1 medications quiet the constant mental chatter about food that doctors call food noise, and when people stop them, in roughly 60% of the people studied blood sugar, blood pressure and waist circumference climb back up as hunger returns.

• What to do: Treat obesity as a medical condition, not a character flaw. Ask your doctor why you do or do not qualify for a GLP-1, and combine medication with strength training, protein, fiber and a registered dietitian rather than waiting to "earn" treatment.
• Why it matters: Hunger is biology shaped by genes, hormones and environment, so shame does not work. The guest says some antidepressants, antipsychotics and steroids drive appetite, and menopause changes how fat is stored.
• How to apply it: If you feel nauseous or constipated on a GLP-1, aim for 25 g of fiber a day for women and 30 g for men, spread protein and fiber across the day, drink around 1.5 liters of fluid and do not raise the dose until symptoms settle. Struggling to reach your protein minimums usually means the dose is too high.
• Metrics: The new lipid guidelines for 2026 aim for LDL under 100, under 70 if lipoprotein(a) is high, and total cholesterol under 200, with screening from age 30. Roughly 1 in 10 women of reproductive age has PCOS.
• Tools: Cost Plus Drugs buys directly from manufacturers and GoodRx finds the lowest prices. The guest paid about $35 at CVS for Repatha with a GoodRx coupon.
• Risks: Compounded GLP-1s skip the FDA approval process and some are mixed with other ingredients. Stop the drug straight away if you become pregnant, and plan a two month washout before conception.
• Exceptions: Not everyone who asks for a GLP-1 qualifies. Someone with a BMI around 23 and PCOS may do better with metformin or a lower impact option.

Motivation does not arrive before action: the feeling follows it, so the fix is the 5 second rule, counting 5-4-3-2-1 and moving the instant you hit one, before your brain can talk you out of it.

• What to do: Answer "what do I want from now on?", pick one small action that a person with that life would take, and count backwards 5-4-3-2-1 to start it even if you do not feel like it.
• Why it matters: Hesitation lasts under 5 seconds before you talk yourself out of a choice, and a streak of 21 days is not a habit. The body keeps its capacity to change at any age, even for a person who has never lifted a weight.
• How to apply it: Put the phone and alarm across the room, lay out workout clothes, leave creatine and a protein shot on the counter, pre-pick the workout the night before and keep treats out of the house. Tie your goal to a personal reason, such as protected time for yourself.
• Metrics: Hyman went from 10 push-ups at 50 to about 75 push-ups and 15 pull-ups after starting to lift at 59; The Let Them Theory sold 11 million copies in 19 months.
• Tools: Function Health lab data, a pre-planned workout, an audiobook for walks, and the ABC model (apologize, back off, compliment) to influence others.
• Risks: Pressuring a loved one to lose weight or take medication triggers resistance. Talk to your doctor before starting hormone therapy or changing medication.
• Exceptions: For big decisions such as a contract or a marriage, stop and think. The 5 second rule is for everyday choices you already know are right.

An average American spends about 12.5 of their final years sick, disabled or in a nursing home, and this video blames chronic inflammation and chronic disease rather than age, which ten habits can push back.

• What to do: Pick one to three of the ten habits and start tonight: get labs, eat fat and animal protein first, cut sugar, grains and seed oils, lift something heavy two or three times a week and sleep at least 7 hours.
• Why it matters: Visceral fat is the most dangerous fat, and in a British Medical Journal study the weakest grip carried about one and two thirds the risk of death of the strongest grip.
• How to apply it: Measure your waist and height with a tape, take private photos every one to three months, fast 12 to 14 hours before blood tests, skip snacks, stand up and sit down every 10 to 15 minutes and raise the head of your bed.
• Metrics: Hemoglobin A1C, fasting insulin, triglycerides, HDL, hs-CRP, vitamin D 25, sex hormones, waist-to-height ratio, five timed floor rises and 10 seconds on each leg.
• Tools: A tailor's tape, light dumbbells, red bricks or 2 by 4 blocks under the bed legs and the Proper Human Diet community for accountability.
• Risks: Snacks of any kind, seed oils, alcohol and sugary breakfasts keep insulin and inflammation high.
• Exceptions: Some people do fine on 6.5 hours of sleep, and a first step can be as small as walking to the mailbox.

You can keep doing hard things by switching between several drivers instead of relying on one, as ultra endurance swimmer Ross Edgley did over a 157 day swim around Great Britain, a 56 hour Yukon swim and 30 marathons in 30 days.

• What to do: Name your spokes before a hard task: because I said I would, fear of letting people down, love, anger, doing it for others, gratitude for what you can do and the absurd hero mindset.
• Why it matters: The anterior mid-cingulate cortex reportedly grows when you do hard things and shrinks when you avoid them, and one driver alone tends to fail during long, painful efforts.
• How to apply it: Focus on the next stroke or step instead of the clock, lower the stakes in your head when pressure builds, protect deep sleep and switch spokes when one fades.
• Metrics: Edgley swam almost 2,000 miles in about 157 days, 317 miles of the Yukon in 56 hours went 70 hours without sleep on the Yukon expedition and uses his pull-up one rep max as a strength reserve.
• Tools: Electrolytes, a glucose wearable, a temperature regulating mattress cover and a protein snack are mentioned as sponsor products, not as part of the model.
• Risks: Motives such as anger or ego can fuel you, but Edgley found records alone felt shallow and sleep loss can drain dopamine and serotonin.
• Exceptions: In ultra endurance an imperfect stroke is fine, while high stakes in precision tasks can overload the motor system and hurt performance.