Fasting feeds Akkermansia, a gut bacterium that eats the intestinal mucus layer, and with no fiber or polyphenols competing for its attention it can overgrow and thin that lining, which fits a Swedish study of about 4,200 people linking high Akkermansia on a low fiber diet to higher type 2 diabetes odds.

• What to do: Stay in the Goldilocks zone. Pair fasting with polyphenol and resistant starch foods such as berries, apple peel and crucifers, and vary your foods instead of repeating the same ones every day.
• Why it matters: Biology follows a U shaped curve, so even a good thing like fasting can drift out of balance over time through accumulation, degradation, attenuation and compensation. Akkermansia is good in balance and harmful when it has only the gut lining to eat.
• How to apply it: Eat foraging style foods the day before a fast (berries, resistant starch, crucifers, lower protein), keep fasts shorter, and treat a small handful of berries during a fast as acceptable. Do not take probiotics daily as a rule. Consider a few weeks only after antibiotics.
• Metrics: About 20 types of mucin are produced in the body. Apple peel carries very long procyanidin chains of roughly 30,000 units. Count calories weekly if at all, not daily.
• Tools: Element 500 mg sodium cans, with 100 mg potassium and 30 mg magnesium, no sugar and no caffeine, sipped through a fast. A CGM and ketone monitor can show how small foods affect you.
• Risks: Repeated long fasts can trigger hyperphagia, a binge urge that grows with a big meal. Daily antioxidants may blunt useful signaling after exercise, and carnivore style diets can raise Akkermansia without fiber to balance it.
• Exceptions: Akkermansia works best when your levels are low. Older adults tend to have more Akkermansia but fewer Bifidobacteria, which can strain the immune system.

Motivation does not arrive before action: the feeling follows it, so the fix is the 5 second rule, counting 5-4-3-2-1 and moving the instant you hit one, before your brain can talk you out of it.

• What to do: Answer "what do I want from now on?", pick one small action that a person with that life would take, and count backwards 5-4-3-2-1 to start it even if you do not feel like it.
• Why it matters: Hesitation lasts under 5 seconds before you talk yourself out of a choice, and a streak of 21 days is not a habit. The body keeps its capacity to change at any age, even for a person who has never lifted a weight.
• How to apply it: Put the phone and alarm across the room, lay out workout clothes, leave creatine and a protein shot on the counter, pre-pick the workout the night before and keep treats out of the house. Tie your goal to a personal reason, such as protected time for yourself.
• Metrics: Hyman went from 10 push-ups at 50 to about 75 push-ups and 15 pull-ups after starting to lift at 59; The Let Them Theory sold 11 million copies in 19 months.
• Tools: Function Health lab data, a pre-planned workout, an audiobook for walks, and the ABC model (apologize, back off, compliment) to influence others.
• Risks: Pressuring a loved one to lose weight or take medication triggers resistance. Talk to your doctor before starting hormone therapy or changing medication.
• Exceptions: For big decisions such as a contract or a marriage, stop and think. The 5 second rule is for everyday choices you already know are right.

A controlled trial where all food was provided showed that a high protein, low carbohydrate diet cut liver fat by 67 percent, about three times more than two other diets, yet ketones were only 0.5 mmol per liter, so protein and carbohydrate restriction, not ketosis, did the work.

• What to do: Raise protein to about 35 grams per meal, pick chicken, fish, tofu and legumes, and keep carbohydrate portions small.
• Why it matters: About one in three adults has fatty liver, and ApoB fell on all three diets once participants lost about 10 percent of their weight.
• How to apply it: Cook with olive, sunflower or rapeseed oil, eat about 25 grams of nuts and 30 grams of fiber daily, and add vegetables to every meal.
• Metrics: 67 percent less liver fat, 23 percent of energy from saturated fat, 0.5 mmol per liter of ketones, apoB, HbA1c and fasting glucose.
• Tools: Eight Sleep Pod 6 for sleep temperature, Function Health lab panels, IM8 multinutrient, Momentous creatine.
• Risks: Saturated fat from butter, cream or coconut oil has no nutritional upside and can raise LDL once weight stabilizes.
• Exceptions: The trial could not isolate saturated fat, did not report vascular function and did not find different glucose tolerance across diets.

Brain scans of people who were overweight or obese looked about 8 years older, and low estrogen, testosterone or thyroid hormone also sped up brain aging, so fixing metabolism, hormones and nutrition can visibly restore brain structure.

• What to do: Treat the brain through the body. Track cardiometabolic health, hormones and nutrients, and add a brain MRI with quantitative analysis plus Alzheimer's blood markers when family history or age 50 to 60 makes them relevant.
• Why it matters: Brain changes can show up about 30 years before Alzheimer's, and around 60% of people diagnosed with dementia have cardiometabolic problems. Scans show recovery after nutrition is restored, as in anorexia, where the brain improved most.
• How to apply it: Get a broad blood panel that includes vitamin D, iron, omega 3, heavy metals, insulin, thyroid, sex hormones, homocysteine and methylmalonic acid, then retest after changes to see your trend.
• Metrics: Alzheimer's incidence doubles every 5 years after age 70, from about 5% at 70 to 10% at 75 and 20% at 80. One APOE4 copy roughly triples risk, and two copies (about 6% of people) raise it 9 to 10 times. Key markers include p tau 217, amyloid beta 42/40, neurofilament light and GFAP.
• Tools: Functional MRI, PET, NeuroQuant brain age and brain charts, plus the Function Health panel. Sponsors named in the episode: Bon Charge red light mask, Paleovalley bars, Timeline Mitopure, Seed DS 01, BiOptimizers magnesium and Fatty15.
• Risks: A single marker or a normal structural MRI can miss the problem, because many psychiatric conditions show up in function, not structure. Imaging is more controversial than blood work.
• Exceptions: Only about 2% of Alzheimer's cases are directly genetic. APOE4 tilts risk but is not destiny, and its effect varies by ancestry.

Sauerkraut is not a probiotic: a probiotic is a specific strain with a known genome and clinical or randomized trial evidence, while the live microbes in sauerkraut, kimchi or kombucha are just live microbes, and only some yogurt brands list strains backed by evidence.

• What to do: Pick supplements or yogurts that print the strain name, take them with food and swap products if you notice no change after a trial period. Eat varied fiber and a mix of ferments such as yogurt, kefir, sourdough, tempeh and sauerkraut.
• Why it matters: Strains of the same species can act oppositely (EHEC E. coli vs the harmless E. coli in your gut), and a 37 study review of fermented dairy found benefits for gut symptoms, serum TNF alpha and gut barrier function.
• How to apply it: Store probiotics cool, dry and away from oxygen. If you avoid dairy, use plant-based yogurt, water kefir or kvass, whose microbes also survive in the gut. Treat commercial stool tests as information, and talk to a doctor or dietitian about persistent symptoms.
• Metrics: 37 fermented dairy studies; kimchi vs cabbage over 3 weeks; fecal calprotectin for inflammation and zonulin for gut wall function.
• Tools: Strain labels and the US probiotic guideline; stool tests only to detect pathogens such as C. diff.
• Risks: Wrongly handled food can carry Clostridium botulinum, and washing produce does not remove all pathogens.
• Exceptions: Most microbes pass through rather than settle, so the benefit depends on regular intake.

Supplements work best as the third layer after behavior and nutrition, and the smartest move is to test one single ingredient formula at a time for about a week, because that is how you find the minimum effective dose and drop whatever does nothing for you.

• What to do: Answer three questions first: how well do you sleep, how good is your nutrition and what is your budget. With about $100 a month or more, start with a broad foundational formula (vitamins, minerals, digestive enzymes, probiotics, prebiotics, adaptogens).
• Why it matters: No supplement or drug can make up for poor sleep, light exposure, exercise and food for long. Ingredients also behave differently in different people, and the ideal dose for you may even be zero.
• How to apply it: For sleep, avoid caffeine after 2 p.m. and food in the last 2 hours. To fall asleep faster, try magnesium threonate or apigenin for one week each. For waking at night, consider 900 mg myo inositol. For focus, keep stimulants (caffeine) separate from neuromodulators (alpha GPC 300 to 600 mg, L tyrosine 500 to 1,000 mg).
• Metrics: Aim for more than 1 g of EPA a day from fish oil. Fadogia agrestis is around 600 mg a day, cycled 8 weeks on and 2 off, or 12 weeks on and 1 month off. Tongkat ali is around 200 to 600 mg a day, with blood work after 8 to 12 weeks. Protein is about 1 g per pound of body weight.
• Tools: Examine.com for ingredient forms, and a high quality omega 3 as the single most impactful supplement.
• Risks: Fadogia agrestis can be toxic to testicular cells at high doses, alpha yohimbine can cause strong anxiety, and melatonin doses are far above natural levels and may not keep you asleep.
• Exceptions: Skip theanine if intense dreams wake you at night. Women should expect some supplements to act differently across the menstrual cycle. Always check with a physician before changing any protocol.

Plaque biofilm that your toothbrush cannot reach hardens into tartar, and that step turns bleeding gums into periodontal disease, an infection that can destroy the bone holding your teeth in place.

• What to do: Clean between your teeth every day with floss, floss picks, interdental brushes or a water flosser. The method matters less than doing it.
• Why it matters: Gum disease is linked with heart disease, diabetes and chronic kidney disease. Diabetes and gum disease affect each other in both directions, so poor gums can make blood sugar harder to control.
• How to apply it: If you have not flossed consistently, start today, because there is always a point in starting. If your gums bleed, keep cleaning gently. Bleeding is usually a sign they need more consistent cleaning, not less.
• Metrics: The progression runs from plaque to gingivitis (red, swollen, tender, bleeding gums) to tartar, then to periodontal disease and, in advanced cases, tooth loss.
• Tools: String floss, floss picks, interdental brushes and water flossers all disrupt the biofilm between teeth.
• Risks: Tartar is hardened plaque attached to the tooth, and neither brushing nor flossing removes it. Only a dental professional can.
• Exceptions: Persistent bleeding can have other causes, so talk to your dental provider. If you have not had a professional cleaning in a while, book one, then restart your routine.

A registered dental hygienist names four 2026 favorites they use and recommend to patients: the Quip Rev oscillating toothbrush, GUM Professional Clean floss picks, Sensodyne Clinical Repair toothpaste and the Quip rechargeable cordless water flosser.

• What to do: Choose an affordable oscillating toothbrush, durable floss picks that do not fray and a sensitivity toothpaste with enamel remineralization, then add a water flosser if you want extra cleaning.
• Why it matters: Technique decides results. Guide an electric brush slowly from tooth to tooth and never scrub, and floss by hugging the tooth up and down on each side.
• How to apply it: Subscribe to brush head refills every 3 months, keep floss picks in your bag, car and desk, and start the water flosser on its gentle mode before moving to deep clean pressure.
• Tools: Quip Rev, GUM Professional Clean Floss Picks, Sensodyne Clinical Repair and the Quip water flosser.
• Risks: The Sensodyne version they use contains SLS, which can irritate some mouths. Check the label for an SLS-free option if you have irritation.
• Exceptions: Sensodyne costs more than some pastes, and the water flosser category is crowded, so compare options if budget matters.

Almost everyone wakes between 1 and 3 a.m. because core body temperature starts rising again after dropping overnight, which moves you into lighter sleep, and what you do in the next few minutes decides whether you drift off or spiral.

• What to do: Skip the bathroom trip unless you truly need it (roll onto your back and count to 20 first), do not check the clock or phone, and start 4 7 8 breathing for 20 cycles.
• Why it matters: Falling asleep needs lower anxiety, temperature and heart rate. Standing up, doing clock math and forcing sleep raises all three, and a heart rate above about 60 makes unconsciousness hard.
• How to apply it: Breathe in for 4, hold for 7 and push out for 8, keeping the exhale longer than the hold. Track cycles by raising a finger each round. Build up with 4 5 6, then 4 6 7, over about a week. If you still cannot sleep, read a boring book in a set chair and return to bed when your eyes feel heavy.
• Metrics: Wake at the same time 7 days a week, because morning light sets melatonin to turn on roughly 14 hours later. Use the 3 2 1 rule: stop food and fluids 3 hours before bed, work 2 hours before, screens 1 hour before.
• Tools: LMNT electrolytes in the morning and an Oura ring to follow weekly trends, not nightly numbers. Counting backward from 300 by threes can also quiet a racing mind.
• Risks: Mouth taping can mask undiagnosed sleep apnea, especially after alcohol. Constantly checking trackers can cause orthosomnia, which is anxiety about sleep data.
• Exceptions: If you truly need to pee, go. If you feel electricity in your body like jet lag, that may be a body clock issue rather than a racing mind.

Yes, you can be insulin resistant with normal blood sugar, because glucose is the last marker to rise while fasting insulin climbs first, and a fasting insulin under 5 is the target almost nobody tests.

• What to do: Ask for fasting insulin, hemoglobin A1C and fasting glucose, then check your waist to hip ratio and body composition instead of trusting glucose alone.
• Why it matters: One patient had glucose under 110 after two colas worth of sugar yet an insulin near 300, and doctors who test only glucose miss many cases.
• How to apply it: Cut starch and sugar, eat protein, fat and 30 grams of fiber, walk 10 to 20 minutes after meals, lift weights, sleep well and fast 12 to 14 hours overnight.
• Metrics: Fasting glucose 70 to 90, fasting insulin under 5, A1C about 5.0 to 5.2, post meal glucose under 110 to 120, waist to hip ratio under 0.8 for men and 0.9 for women.
• Tools: Function Health tests with an insulin resistance score from 0 to 100, a continuous glucose monitor for a few weeks and a tape measure.
• Risks: Statins, sleep apnea, chronic stress and artificial sweeteners can worsen insulin resistance or cravings.
• Exceptions: A glucose spike after eating is normal, and thin people can still carry hidden fat, so body composition matters more than weight.